What is the proper technique for opening sterile vials during compounding?

The proper technique for opening sterile vials during compounding is to use aseptic technique, minimizing contact with the vial's interior. This is essential to ensure sterility and to prevent contamination of the contents inside the vial. Aseptic technique encompasses a range of practices that maintain a sterile environment, such as using gloves, sanitizing surfaces, and employing proper opening methods to reduce the risk of introducing contaminants.

When opening a vial, it is crucial to handle it carefully and ensure that only sterile surfaces come into contact with the contents. This not only protects the sterile integrity of the medication but also safeguards patient safety by preventing possible infections or adverse reactions due to contamination. Applying these principles is part of the broader requirements set forth in USP 797, which aims to uphold high standards for sterile compounding practices.