What is the frequency for surface sampling in a cleanroom according to USP 797?

Surface sampling frequency in a cleanroom is vital for ensuring the maintenance of an aseptic environment. According to USP 797 guidelines, high-touch surfaces, which are those that are contacted frequently and may harbor more potential contaminants, should be sampled monthly. This frequency allows for adequate monitoring of these critical areas to confirm that they are effectively cleaned and maintained, thereby minimizing the risk of microbial contamination during sterile compounding activities.

High-touch surfaces typically include items like countertops, equipment handles, and other frequently handled instruments within the cleanroom. Monthly sampling of these areas is a balanced approach, as it ensures regular oversight without being overly burdensome, allowing for prompt corrective actions should any issues arise. This adheres to the guidelines of maintaining a high standard of cleanliness and ensuring patient safety through effective sterile compounding practices.