What is a significant reason for changing gloves during the compounding process?

Changing gloves during the compounding process is crucial to maintaining a sterile environment. In sterile compounding, the primary goal is to prevent contamination of the products being prepared. Gloves can become contaminated due to contact with non-sterile surfaces, materials, or even skin. By changing gloves at appropriate times in the compounding process, compounding personnel can significantly reduce the risk of introducing pathogens or particulate matter into the sterile preparation.

Maintaining a sterile environment is integral to ensuring patient safety, especially for those receiving medications that will bypass their body's natural defenses, such as through injections. This practice aligns with the principles established in USP 797, which emphasizes the importance of aseptic techniques in preventing contamination. Therefore, changing gloves at designated times acts as a critical barrier in the overall process of compounding sterile products.