How should CSPs that require reconstitution be handled?

CSPs (Compounded Sterile Preparations) that require reconstitution must follow specific guidelines to ensure their safety, efficacy, and sterility. Proper handling is crucial because reconstitution typically involves the addition of a diluent to a dry powder to create a solution or suspension for administration.

Adhering to established guidelines helps minimize the risk of contamination, which is vital in a sterile environment where even the slightest contamination can lead to serious complications for patients. It also ensures that the CSP reaches the correct concentration and maintains its intended pharmacological effect, which is essential for patient safety.

By carefully following protocols for reconstitution, such as using aseptic techniques, utilizing appropriate equipment, and storing the reconstituted preparation correctly, pharmacists can effectively reduce the potential for errors and safeguard patient health. This level of care and adherence to guidelines is a fundamental principle of sterile compounding as outlined in USP 797 compliance.