For which of these compounding activities is the use of a glove box unsuitable?

The use of a glove box, also known as a compounding aseptic containment isolator (CACI), is not suitable for high-risk compounding primarily because high-risk compounding involves a greater potential for contamination during the preparation process. In high-risk compounding, the handling of non-sterile ingredients or the use of non-sterile device surfaces can increase the likelihood of microbial contamination and endotoxin exposure.

Glove boxes are designed to provide a barrier between the compounding environment and the external surroundings, but they may not reach the necessary sterility assurance levels required for high-risk compounding. High-risk compounding usually requires a controlled environment that can ensure a higher level of sterility assurance, such as a sterile environment found in laminar airflow workbenches or cleanrooms. These environments are typically designed to maintain lower levels of airborne contamination and enhance the sterility of compounded preparations.

In contrast, low-risk and moderate-risk compounding activities generally involve procedures that do not carry the same level of contamination risk and can be appropriately managed within a glove box. IV admixture, depending on the complexity, can also often be conducted in a glove box if the proper procedures are followed to prevent contamination.