For how long should the LAFW blowers run before starting compounding activities?

The correct duration for running the Laminar Airflow Workbench (LAFW) blowers before commencing compounding activities is 30 minutes. This timeframe is important because it allows for the establishment of unidirectional airflow, ensuring the workspace is adequately cleared of particles and contaminants. The 30-minute pre-operation run time supports the reduction of microbial load in the area where sterile products will be prepared.

This practice is aligned with the guidelines outlined in USP 797, which emphasizes the importance of maintaining a sterile environment for compounding. Continual airflow helps to displace potentially harmful particles, thereby creating a safer workspace for both the compounder and the products being prepared. The flow of HEPA-filtered air also must reach optimal levels, which can take some time, making 30 minutes a reasonable and effective standard in practice.

While other times such as 15 minutes, 45 minutes, or one hour may be suggested in various settings or by different institutions, the proper consensus within the professional community is that 30 minutes is the most effective and widely accepted practice based on aseptic technique and environmental safety standards.